Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses

Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.

Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute t...

Population of Monocyte-Derived Macrophages

Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Duan Kaibo, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin,* and Muzlifah Han...

Quantification and comparison of TLR2 activity in monocyte-derived macrophages of zebu and crossbred cattle

The present study was conducted to quantify and compare TLR2 (toll-like receptor 2) activity in monocyte-derived macrophages of zebu (Tharparkar) and crossbred (Holstein-Friesian × Jersey × Brown Swiss × Hariana) cattle. The cells were either induced with Pam3CSK4 or kept as control. The TLR2 activity was quantified in terms of IκB-α inhibitory subunit (NFKBIA) messenger RNA (mRNA) copies...

Monocyte-Derived Dendritic Cells Th17 Cells Induce Th1-Polarizing

Monocyte-Derived Macrophages Cytokine Responses by Human Monocytes Fas (CD95) Induces Proinflammatory